MS and Viagra as a Treatment

   

A picture of me.

That would be me!

     I was reading another site and was stunned to read that researchers are studying Viagra as a treatment for Multiple Sclerosis. The following is what I found in a internet search and I’m still a bit surprised since this is the first I’ve heard of it.

Universitat Autònoma de Barcelona researchers have discovered that Viagra®  (sildenafil) drastically reduces multiple sclerosis symptoms in animal models with the disease. The research, published in Acta Neuropathologica, demonstrates that a practically complete recovery occurs in 50% of the animals after eight days of treatment. Researchers are confident that clinical trials soon will be carried out in patients given that the drug is well tolerated and has been used to treat sexual dysfunction in some multiple sclerosis patients.

Multiple sclerosis is the most common chronic inflammatory disease of the central nervous system and one of the main causes of disability among young adults. The disease is caused by the presence of multiple focuses of demyelination (loss of myelin sheaths around the axons, affecting the ability of neurons to communicate) and neurodegeneration in different areas of the central nervous system. There is currently no cure for the disease, although some drugs have proven effective in fighting symptoms and preventing it from progressing.

A research team from the UAB Institute of Biotechnology and Biomedicine directed by Dr Agustina García, in collaboration with the research team directed by Dr Juan Hidalgo from the UAB Institute of Neurosciences, has studied the effects of a treatment using sildenafil, sold as Viagra®, in an animal model of multiple sclerosis known as experimental autoimmune encephalomyelitis (EAE). Researchers demonstrated that a daily treatment with sildenafil after disease onset quickly reduced clinical signs, with a practically complete recovery in 50% of the cases after eight days of treatment. Scientists observed how the drug reduced the infiltration of inflammatory cells into the white matter of the spinal cord, thus reducing damage to the nerve cell’s axon and facilitating myelin repair.

Sidenafil, together with tadalafil (Cialis®) and vardenafil (Levitra®), form part of a group of vasodilator drugs known as phosphodiesterase type 5 (PDE5) inhibitors, used in the treatment of erectile dysfunction and pulmonary arterial hypertension. Recent studies in animal models of central nervous system pathologies already pointed to the fact that in addition to vasodilation, these drugs could contain other neuroprotective actions and suggest their usefulness as possible treatments of both acute (cerebrovascular stroke) and chronic (Alzheimer’s) neuropathologies.  Research published in 2010 in theJournal of Neurochemistry by the same research group from UAB demonstrated that one of these inhibitors reduced neuroinflammation and neuronal damage in animal models of traumatic brain injury.

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13 thoughts on “MS and Viagra as a Treatment

  1. SANFORD H SIEGEL JR

    You know a lot of folks are trying different things and That is good. What is NOT good are people that jump the gun and take a TEST as a CURE. RULE #1: UNLESS A PARTICULAR TREATMENT RETARDS OR REPLACES THE MYELIN IN THE BRAIN/SPINE, THAT PARTICULAR TREATMENT DOES NOT HELP THE DISEASE OF MS. THESE ARE FACTS AND THESE FACTS CAN NOT BE DISPUTED. Sooooo before you start popping Viagra let the long term study do its job. IN THE MEANTIME, YOUR BEST BET, IN FACT YOUR ONLY BET, IS TO GO SEE YOUR DOCTOR AND DO WHAT HE/SHE SAYS!!!.

    Reply
  2. Damon Bailey

    I think I’ve heard it all, its a boner pill now, what drug companies will do to sell there product or services. Last week the cure was a build up of iron in the brain. So everyone becareful of scams and put your wallet away, consult with doctor that specialized with MS. I’ve been dealing with this disease for the last 25 years and wish research one day have a clue or direction.

    Reply
    1. msandbeyond Post author

      Hi Kit, I probably will ask about this but insurance will not cover Viagra. And at a cost of $28.00 a pill it’s a bit spendy as a daily treatment. I will follow the research though because it does increase blood flow which is what some people believe may have a big effect on the stopping MS! Will see?

      Reply
  3. Tony S

    It does make some sense. Viagra increases the blood flow and oxygen delivery. Just as some MS patients benifit from hyperbaric oxygen to repair lesions maybe the viagra will help repair after a relapse. (Strangely enough my wife has ms and pulmonary hypertension and has viagra as her PH treatment.) Her MS was stable before the PH came along so it’s hard to see if there is an improvement)
    Tony

    Reply
  4. click

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  6. Tony Seaton

    It very interesting as my wife has ms and pulmonary hypertension. She developed pulmonary hypertension after being on rebif for 10 years. There may or may not be a link.
    However…. She is on sildenifil 75mg three times a day. I can assure you I have seen no change in her MS. She moved from rebif to copaxone as rebif has a small number of PH cases emerging and copaxone has different method of working.

    She is also on warfarin to thin the blood and mecatentan to increase the sats (oxygen carried in the blood)

    So anicdotal evidence of one case, doesn’t work!

    Reply
  7. Rachel Widnall

    HOW I WAS CURED TOTALLY FROM MULTIPLE SCLEROSIS
    I had my first attack of multiple sclerosis (MS) when I was 33, I wasn’t diagnosed until seven months later when I became totally numb from the neck down. It was so terrifying that I began dropping things and losing the dexterity in my fingers, having severe fatigue and muscle weakness. A horrible itch began on my chest with no rash present. I sometimes can’t walk straight and fall onto walls and I get random prickles in my hands and legs.all the English medications i used proved abortive. i was so frustrated that i had to contact My neurologist,he told me about a new RRMS (relapsing-remitting MS) drug which was only in its trial stage, CAMPATH. I started the chemo-type treatment and some prescribed drugs like: AVONEX, BETASERON, COPAXONE and REBIF. which resulted in 1st seizure of my life, thereby adding more salt to my injury. As a result to proffer solution to my problems, i started going online in search for a cure, i came across a testimony of a woman who got her cure through HERBAL MEDICATION, at first, i doubted because of the misconception that multiple sclerosis can not be cured. But i later contacted the Doctor through the email provided, and I used his Herbal product, after 1 month of use, I noticed tremendous improvement in my health, 5 months after, I can proudly say, I’ve been totally cured by Dr.Allen’s Herbal Medication from MULTIPLE SCLEROSIS…, If you have the same health issue, you may contact him for a total change of story, Via: drallenchase@gmail.com. I believe your predicament will be a thing of the past just like mine.

    Reply

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