MS and Stem Cell Particles

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Bill Walker                                                                   

This is a reprint from a recent study:

Dr. Metcalfe, who is based at Cambridge University in England, is currently looking for funding to further develop her theory that using a stem cell particle called a LIF would switch off the body’s auto-immune cells and help repair the brain.

In addition to being able to switch off the body’s autoimmune response, LIF also protects the brain and spinal cord — the areas affected by multiple sclerosis — and aids in repairing tissue, including brain tissue.

The research has not been smooth sailing. Metcalfe has found that LIF cannot survive outside the cell for more than 20 minutes before being broken down by the body, making it difficult to use as a therapy. However, she has found that nanoparticles could be the answer to the problem, as they can be used to help deliver the LIF therapy. By using antibodies with the nanoparticles, the therapy can be directed to certain areas of the brain — helping to repair damage caused by multiple sclerosis.

Metcalfe is now looking for research funding and hopes that one of the big pharmaceutical companies will step in. She hopes to begin clinical trials of the therapy by 2020.

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MS and Gut Bacteria

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Bill Walker

This is a reprint from a recent study.

A study has found that microbes in your gut may influence the progression of multiple sclerosis (MS). It could be a key step towards specific treatment, and help solve what causes MS.

Published in the Proceedings of the National Academy of Sciences, two different teams conducted separate research and made the same findings. One was from the University of California, San Francisco, and the other from the Max Planck Institute in Germany.

The first team investigated the gut microbiomes of 71 MS patients and 71 control subjects. They identified specific species of bacteria that were more common in the former than the latter. Next, they exposed these bacteria to human immune cells, and found that two species triggered cells to become pro-inflammatory. One found at lower levels triggered immune responses.

In tests on mice, they found that these bacteria had a similar effect. Replacing mice microbiomes with those from an MS patient caused the mice to lose immune-regulatory cells and develop neurodegeneration, a pathway to MS.

The second study came to a similar conclusion, finding that microbiome transplants could increase symptoms in mice.

“Two different groups, using two separate cohorts of patients and controls, and two distinct mouse models of the disease, saw very similar results,” Egle Cekanaviciute said in a statement, who was involved in both studies. “This is very promising evidence that we’re on the right track.”

MS affects about 2.5 million people across the globe, and is known as an autoimmune neurodegenerative disorder. It can lead to loss of vision, weakness, and even paralysis. It’s caused by the immune system attacking the insulation around nerve cells, called myelin, but scientists have been at a loss to explain why this occurs.

These latest studies could provide an answer. While the microbiome probably isn’t the only trigger, it could play a role. This could lead to some new treatments in the future to help tackle MS.

“The microbiome is very malleable,” said Sergio Baranzini, also involved in both studies. “You could relatively easily change it in an adult who has MS or is susceptible – something you cannot do with their genetics. This is not a magical approach, but it is hopeful.”

MS and Reducing Summer Car Heat

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Bill Walker

We all know that summer heat and humidity are absolutely brutal on people with multiple sclerosis. And escaping it is almost impossible to do. But one area where everyone, ms or not dreads is getting into a car that has been sunbathing for a few hours and the internal temperature is usually somewhere in the 120 degree range.

There is a somewhat easy choice to reduce some of that direct sunlight. You’ve probably already seen them and perhaps laughed at some of the more goofy ones. If you’ve ever wondered if those car screens in the front window, and occasionally in the back as well, work? They do, and are very effective in keeping your car from becoming a roaster oven.

You can buy these screens at Walmart and other similar stores. And also keep your windows cracked open just enough to let any heat that may build up to escape. You can also invest in solar powered window fans that run off the power of the sun while your not in the car keeping the air moving so the heat moves out any cracked windows.

Try to stay cool and have a great summer everybody!

Bill Walker

Do you know a literary agent or book publisher that would be willing to read my book? If so please email me and let me know. 

MS a Child with Cancer and a Kitten

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Bill Walker

The power of having a pet, in this case a kitten, can change people’s lives forever. The following true short story was published in Parade Magazine a few weeks ago. And though it is not about multiple sclerosis it is nothing but pure love, so I decided to share it here. It brings hope that any disease can be cured!

 

ONE LAST WISH

 

Robin and Mark Myers, of Suwanne, GA., are grateful for the rescue that came into their family’s life when their 12-year-old daughter, Kylie, was battling cancer.

     “Cancer stole a lot from Kylie, but she was determined it wouldn’t steal her joy,” says Robin. When the family got the news that Kylie was dying. She looked up with a weak smile and a twinkle in her eye, asking her dad, “Now can I finally have a kitten?” Sharing their story on what would have been Kylie’s 15th birthday, Robin recalls, “We would’ve said yes to anything.”

     A friend swung by the local shelter and rushed to Kylie’s bedside with a kitten. Kylie named her Liza and the kitten curled up in the crook of her arm. “Liza just stayed there and didn’t leave her side at all in the few days until we lost Kylie,” Robin recalls through tears. “The last thing Kylie said was, ‘I want you to help find a cure for childhood cancer, and please take care of my kitty.’

     “But it’s Liza, who takes care of me, “says Robin. “When I cry, Liza comes running. She has an uncanny understanding. She rescued our family and keeps Kylie’s spirit alive.” (Visit Parade Magazines website for a video. Sorry, many sites that I publish on will not permit links.)

    

     (The FDA just approved a way to enhance the body’s own immune system to attack, Lymphoma, a form of blood cancer, which has been effective in curing 85% of the patients that have received this new breakthrough treatment. It is hoped that this treatment can one day soon be developed for use in all types of cancers for both humans and pets as well. Making cancer a disease of the past!)

 

Please support your local shelter and adopt whenever you can. And always get your pets spay or neutered.

Bill Walker

MS Turmeric and Inflammation

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That would be me!

     Turmeric is derived from the spice curry used extensively in India. It’s health benefits range from helping to treat constipation to also being a huge anti-inflammatory agent. I personally had read so many great things about turmeric , including that some people believed it have something to do with India’s very small incidence of Multiple Sclerosis, that I just had to give it a try. 

     That was over a year ago and unfortunately I did not experience the health benefits that I had hoped to achieve. I am certainly not saying that it doesn’t provide benefits to other people but it doesn’t seem to do much for me except cost money. It may come down to each persons own body chemistry being a factor in whether turmeric has a positive effect or not. I know that researchers are discovering that many cancer drugs can work wonders for some people and have absolutely little if any effect for others.

     In closing, if it works for you, by all means keep using it as long as your neurologist and general practitioner are aware of you using it as many supplements like turmeric can have undesirable effects when used with other prescribed drugs!   

by

Bill Walker

 

PS. I am still in search of a literary agent/publisher for my book if anyone can help by putting in a good word for me!

MS Donald Trump and His Medicaid Budget Cuts

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That would be me!

No matter how you voted or what your personal political beliefs are of Donald Trump and his administration, the 2017-2018 budget that was just released, is nothing short of draconian with respect to anyone who has a disability.

This budget calls for cuts of up to 1.4 Trillion, yes Trillion, dollars to medicaid over the next ten years. This will mean every single person with a disability that relies on medicaid for health care, including children, will be impacted.

Donald Trump has also asked for cuts of hundreds of millions of dollars from the social security fund that provides disability checks for both Veterans and people living with disabilities. And, on top of that, his administration is also seeking large cuts to the Snap program that helps people with disabilities buy food through the use of food stamps to help supplement their disability checks.  

People with disabilities need to stand as one and say, “NO!” to these outrages cuts.

Bill Walker

MS Oral Medications Cholesterol Constipation and Metamucil

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That would be me!

Multiple Sclerosis, being a nerve disease, often can cause the person with ms to experience constipation. But did you know that if you use one of the approved oral medications for multiple sclerosis, or any oral medication for that matter, and also taking metamucil which uses psyllium husk as its main ingredient you could be blocking your bodies ability to absorb your medication?

Bulk-forming fiber like psyllium husk can effect how well your body can absorb medicines taken by mouth. If you are on a oral ms drug or other oral medication you need to take your medications either two hours before or after you take something like metamucil no matter whether it is in pill form or mixed in water and drank. And this would also include the use of bulk-forming fiber as a treatment for high cholesterol as well.

For more dietary suggestions ask your doctor or get a referral to a registered dietitian!